- Case Report
- A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate
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Seon Woo Lee, Eun Hye Park, Hyun-Sang Cho, Jae Kook Cha, Hae Ran Lee
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Clin Exp Pediatr. 2001;44(9):1066-1069. Published online September 15, 2001
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Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis
and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia
and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of
meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG-
1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of
urinary incontinence,... |
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- Original Article
- Bystander Effect of HSV-TK/GCV Gene
Therapy in Murine Neuroblastoma
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Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee
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Clin Exp Pediatr. 2001;44(11):1249-1253. Published online November 15, 2001
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Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo.
Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK＋ or HSV-TK－ were plated into culture plates and treated with GCV for... |
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- Case Report
- A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
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Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
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Clin Exp Pediatr. 2000;43(7):974-977. Published online July 15, 2000
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Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular
breakdown products into the circulation due to massive cytolysis occurring before start of treatment.
It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well
described, following cytotoxic chemotherpy and other single agent administrations. However, only a
handful of spontaneous acute tumor lysis... |
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- A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
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Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
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Clin Exp Pediatr. 2000;43(7):974-977. Published online July 15, 2000
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Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular
breakdown products into the circulation due to massive cytolysis occurring before start of treatment.
It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well
described, following cytotoxic chemotherpy and other single agent administrations. However, only a
handful of spontaneous acute tumor lysis... |
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- A Case of Septic Pulmonary Emboli in Ventricular Septal Defect
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Keum Bong Jee, Jae Kook Cha, Kon Hee Lee, Kwan Seop Lee
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Clin Exp Pediatr. 1999;42(2):279-283. Published online February 15, 1999
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Septic pulmonary emboli(SPE) is derived from a variety of sources, including infected heart valves, peripheral sites of septic thrombophlebitis and infected venous catheters or pacemaker wires. In adult intravenous drug users, the most common cause of septic emboli is tricuspid valve endocarditis, but infective endocarditis in the non-complicated ventricular septal defect is a relatively rare condition in infants and... |
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- Three Cases of Acute Focal Bacterial Nephritis
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Yeon Soo Lim, Jae Kook Cha, Kon Hee Lee, Kwan Seop Le
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Clin Exp Pediatr. 1999;42(1):138-142. Published online January 15, 1999
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Acute focal bacterial nephritis(AFBN) is an unusual form of localized renal infection, which has various imaging findings and should be distinguished from abscess or other renal masses. Clinical symptoms are similar to other urinary tract infections but the diagnosis needs a CT or sonographic confirmation. Treatment, which is nonoperative, consists of intensive antibiotic therapy. We report three cases of AFBN... |
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- Case Report
- A Case of Ectopic Pancreas with Malrotation
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Il Song Kang, Kil Soo Chung, Jae Kook Cha, Kon Hee Lee, Kwan Seop Lee, Byung Chun Kim, Eun Sook Nam
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Clin Exp Pediatr. 1998;41(10):1438-1441. Published online October 15, 1998
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Ectopic pancreas is defined as pancreatic tissue lacking anatomical and vascular continuity with the main body of the pancreas. Common symptoms are epigastric pain, hemorrhage, chest pain, weight loss, nausea and vomiting. A 2-month-old male patient was hospitalized because of continuous bile stained vomiting for 2 days. Abdominal ultrasonography and colon study showed malrotation of the intestine. Surgical exploration revealed... |
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- A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
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Nan Yee Kye, Kon Hee Lee, Jae Kook Cha, Hye Sun Yoon, Won Keun Song
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Clin Exp Pediatr. 1997;40(4):578-583. Published online April 15, 1997
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We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome.
The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension.
Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC... |
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- Original Article
- Comparison of Antimicrobial Susceptibility of Nosocomial and
Community-Acquired Pathogens in Children of Medium-Sized Hospital
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Kil Soo Joung, Jae Kook Cha, Kon Hee Lee, Hye Sun Yoon, Wonkeun Song
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Clin Exp Pediatr. 1997;40(11):1537-1543. Published online November 15, 1997
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Purpose : We evaluated the identification and antimicrobial susceptibility patterns of nosocomial
and community-acquired pathogens in children of the medium-sized hospital.
Methods : The 357 bacterial strains isolated from Pediatric department of Dongsan Sacred Heart
Hospital were examined the species identification and antimicrobial susceptibility test during the
period of March to October 1996.
Results : Fifty three strains(15%) of 357 strains were nosocomial pathogens. A... |
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